Bryxta bevacizumab 400mg injection is used by doctors to treat various cancers such as colon, rectum, non-small cell lung cancer, kidney cancer, brain tumors, ovarian, and cervical cancer. The medication works by inhibiting the growth of new blood vessels that supply tumors and preventing their growth.
Bryxta bevacizumab 400mg injection often used in the People as a first-line treatment in combination with other cancer therapies. Infusion administration involves inserting a small needle into a vein, a port, or a device under the skin. Your doctor will determine the appropriate dosage and duration of treatment while also monitoring for any infusion reactions, such as high blood pressure or breathing difficulties. As long as your condition is under control and the side effects are manageable, you will continue to receive Bryxta. Your doctor will decide if and when to discontinue the treatment. During treatment, your doctor may advise regular monitoring of blood pressure and urine protein levels.
Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Additionally, disclose all other medications you are taking, as many medicines can interact with Bryxta.
Uses of Bevacizumab Injection
1. Cancer of the colon and rectum
2. Ovarian cancer
3. Cervical cancer
4. Kidney cancer
5. Brain tumor
6. Non-small-cell lung cancer
How to use Bevacizumab 400mg Injection
Bevacizumab 400mg injection is given through inserting a small needle into a vein, a port, or a device under the skin. Your doctor will determine the appropriate dosage and duration of treatment. Kindly do not self-administer.
How to Becacizumab Injection works
Bevacizumab 400 injection is an anti-angiogenic medication. It works by inhibiting a protein called vascular endothelial growth factor (VEGF), which prevents the formation of blood vessels that supply oxygen and nutrients to cancer cells.
Therapeutic Effects of Bevacizumab
Bryxta 400mg Injection is a recombinant humanized monoclonal antibody used as a targeted therapy for various advanced cancers. It works by selectively binding to the vascular endothelial growth factor A (VEGF-A) protein, which is present in the lining of blood and lymph vessels. By disrupting VEGF-A's interaction with its receptors, it inhibits the formation of blood vessels that supply oxygen and nutrients to the tumor, slowing cancer progression.
Interaction of Bryxta 400mg injection with other drugs
Prior to treatment, inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken. Certain medications may interact with Bryxta 400mg injection, potentially leading to undesirable side effects.
More information about Bryxta 400mg Injection
1. Store Bryxta 400mg Injection at 2˚C to 8˚C. Do not freeze or shake.
2. Protect from light. Keep out of reach of children.
Piece of Advice
It is essential to inform your physician before taking Bryxta 400mg Injection if you have any of the following conditions:
1. They suffer from conditions that cause inflammation in the stomach, such as ulcers and colitis.
2. Experience allergic reactions to the Bryxta 400 mg injection or its ingredients.
3. I recently underwent surgery due to the risk of bleeding.
4. Have diabetes, hypertension, or heart problems.
Fact box of Bryxta 400mg Injection
1. Molecule name: Bevacizumab
2. Therapeutic class: Anticancer
3. Pharmacological class: VEGF Inhibitor
4. Indications:
1. Glioblastoma multiforme (brain cancer)
2. Persistent, recurrent, or metastatic breast cancer
3. Metastatic cervical cancer
4. Advanced kidney cancer
5. Metastatic colorectal cancer
6. Advanced non-small-cell lung cancer
7. Liver Cancer- Hepatocellular carcinoma
8. Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer
References
1. Roche Products Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2022] [Accessed on 21/11/2022], https://www.medicines.org.uk/emc/files/pil.3885.pdf
2. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
3. G.G. Dark, A.R. Abdul Razak, Oncology, Davidson's Principles & Practice of Medicine, 22nd Edition, 2014, 259-282.
4. Roche Group, U.S FDA, [Revised on Jan 2021][ Accessed on 21/11/2022],https://www.gene.com/download/pdf/avastin_prescribing.pdf
5. Roche Group,Bevacizumab Injection, Indication,[Revised on 2020] [Accessed on 21/11/2022]https://www.avastin.com/patient/mcrc.html
FAQ - Bevacizumab
1Is Bryxta 400mg Injection used as a standalone treatment for cancer?
Bryxta 400mg injection is a recombinant monoclonal antibody classified under immunotherapy for cancer treatment. You can administer it as monotherapy or in combination with chemotherapy or other immunotherapy medications to enhance overall survival rates.
2Is it safe for women to use Bryxta 400mg Injection?
For women of reproductive potential undergoing treatment with Bryxta 400mg Injection, it is crucial to discuss effective birth control methods with your doctor. Use contraception during treatment and for at least 6 months after completing the course, as this medication may impair fertility.
3Is it safe to undergo surgery during the treatment with Bryxta 400mg injection?
Bryxta 400mg Injections are associated with an increased risk of bleeding complications and impaired wound healing. We advise against planning surgery and maintaining a 28-day interval before or after surgery.
4Do the side effects of Bryxta 400mg injection last for a chronic period?
All side effects caused by Bryxta 400mg injection generally persist as long as the drug remains in the body. We have observed that this medication remains in the body for approximately 4 months after the final dose.
5How is the Bryxta 400mg injection administered?
Bryxta 400mg Injections are administered intravenously via infusion. We calculate the dosage based on the patient's body weight, height, and age. Typically, we administer the initial dose over a period of 90 minutes. You can reduce subsequent infusion times to 30 minutes if the patient tolerates this well.
6Can I take Bryxta 400mg injection if I am pregnant?
Inform your physician before beginning treatment with Bryxta 400mg injection if you are pregnant or planning to become pregnant, as this medication can harm the unborn baby and interfere with blood vessel formation.
7Bevacizumab price
Bevacizumab price is INR 12000
8Bevacizumab mechanism of action
Bevacizumab is a recombinant humanized monoclonal antibody that targets vascular endothelial growth factor A (VEGF-A). VEGF-A is a protein that promotes angiogenesis, the formation of new blood vessels, which is crucial in various diseases, particularly cancer. By binding to VEGF-A, bevacizumab prevents it from interacting with receptors on the surface of endothelial cells. This action reduces VEGF activity, thereby inhibiting angiogenesis and decreasing vascular permeability.
9Bevacizumab 400 mg price in india
Bevacizumab 400 mg price in india: INR 12000
10Bevacizumab 400mg price in india
Bevacizumab 400mg price in india: INR 12000
11Bevacizumab 400 mg price
Bevacizumab 400 mg price: INR 12000
12Bevacizumab 400mg price
Bevacizumab 400mg price: INR 12000
13Bevacizumab price in India
Bevacizumab price in India: INR 12000
14Bevacizumab price
Bevacizumab price: INR 12000
15Bevacizumab 400 mg price Reliance
Bevacizumab 400 mg price Reliance: INR 14000
16Bevacizumab 400 Mg brands in India
Bevacizumab 400 Mg brands in India
1. Bevnexxa: from Celon Labortories Ltd.
2. Bevaza: from Lupin Ltd
3. Bevacirel: from Reliance Life Sciences Pvt Ltd
4. Cizumab: from Hetero Healthcare
5. Versavo: from Dr Reddy`s Laboratories Ltd
6. Abevmy: from Mylan Pharmaceuticals Pvt Ltd
7. Bevatas: from Intas Pharmaceuticals Ltd
8. Avastin: from Roche Products India Pvt Ltd
17Bevacizumab 400 mg side effects
Side effects are unwanted symptoms caused by medications. While all medicines have the potential to cause side effects, not everyone will experience them.
Common:
1. Numbness in hands or feet
2. Weakness and lack of energy
3. Diarrhoea, nausea, vomiting, abdominal pain
4. Constipation
5. Loss of appetite
6. Weight loss
7. Changes in taste and speech
8. Decrease in counts of white blood cells
9. Fever
10. Dry skin
11. Back pain
Serious:
Serious:
1. Headache
2. Vision changes
3. Confusion
4. Severe allergic reactions
5. High Blood pressure
6. Delayed wound healing following surgery
7. Protein in urine
8. Severe infections
9. Blood clots in arteries and blood vessels of lungs
10. Gut perforation
11. Nosebleeds and bleeding risk
12. Heart problems with an increase in heart rate
13. Mouth sores, dryness
14. Shortness of breath
18Bevacizumab Injection price
Bevacizumab Injection price: INR 12000
19Bevacizumab chemotherapy
Bevacizumab (Avastin) is a targeted cancer therapy that operates differently from chemotherapy. You can administer this monoclonal antibody medication as a slow injection into a vein or through an intravenous drip. By inhibiting a protein that promotes the growth of blood vessels in tumors, bevacizumab treats various types of cancers and certain eye diseases. By blocking this protein, bevacizumab can slow the growth and spread of tumors.
20Bevacizumab structure
Bevacizumab is a recombinant humanized immunoglobulin-G monoclonal antibody that has a complex structure.
1. Bevacizumab consists of two identical light chains and two heavy chains. The light chains have 214 amino acid residues, while the heavy chains have 453 residues.
2. Bevacizumab has variable (VH and VL) and constant (CH and CL) regions.
3. Specificity sequences for mice: Bevacizumab also has six specificity sequences for mice attached to its heavy and light chains that are linked by disulfide bonds.
21Bryxta 400 mg price
Bryxta 400 mg price: INR 12000
22Bryxta 400 side effects
Bevacizumab Injection side effects
Side effects are unwanted symptoms caused by medications. While all medicines have the potential to cause side effects, not everyone will experience them.
Common:
1. Numbness in hands or feet
2. Weakness and lack of energy
3. Diarrhoea, nausea, vomiting, abdominal pain
4. Constipation
5. Loss of appetite
6. Weight loss
7. Changes in taste and speech
8. Decrease in counts of white blood cells
9. Fever
10. Dry skin
11. Back pain
Serious:
Serious:
1. Headache
2. Vision changes
3. Confusion
4. Severe allergic reactions
5. High Blood pressure
6. Delayed wound healing following surgery
7. Protein in urine
8. Severe infections
9. Blood clots in arteries and blood vessels of lungs
10. Gut perforation
11. Nosebleeds and bleeding risk
12. Heart problems with an increase in heart rate
13. Mouth sores, dryness
14. Shortness of breath
23Bryxta 400 Injection
Bryxta Injection
Bryxta 400 Injection is used by doctors to treat various cancers such as colon, rectum, non-small cell lung cancer, kidney cancer, brain tumors, ovarian, and cervical cancer.
24Bryxta 400mg price
Bryxta 400mg price: INR 12000
25Bevacizumab 400mg injection
Bevacizumab 400mg injection
Bevacizumab 400mg Injection is an anticancer medication used to treat various types of cancer, including colorectal cancer, non-small cell lung cancer, kidney cancer, brain tumors, ovarian cancer, and cervical cancer. It works by inhibiting the formation of new blood vessels that supply nutrients to tumors, thereby preventing their growth.
26What is the price of Bevacizumab 400mg injection price in india
The price of the Bevacizumab 400mg injection in india is INR 12000
Side effects are unwanted symptoms caused by medications. While all medicines have the potential to cause side effects, not everyone will experience them. Common:
1. Numbness in hands or feet
2. Weakness and lack of energy
3. Diarrhoea, nausea, vomiting, abdominal pain
4. Constipation
5. Loss of appetite
6. Weight loss
7. Changes in taste and speech
8. Decrease in counts of white blood cells
9. Fever
10. Dry skin
11. Back pain Serious:
Serious:
1. Headache
2. Vision changes
3. Confusion
4. Severe allergic reactions
5. High Blood pressure
6. Delayed wound healing following surgery
7. Protein in urine
8. Severe infections
9. Blood clots in arteries and blood vessels of lungs
10. Gut perforation
11. Nosebleeds and bleeding risk
12. Heart problems with an increase in heart rate
13. Mouth sores, dryness
14. Shortness of breath
