Doctors prescribe Siromus Sirolimus 1mg tablet to transplant recipients to prevent organ rejection. It functions by regulating the body's immune response, allowing the transplanted organ to be accepted.
You should take Siromus 1mg tablets according to the prescribed dose and duration. You can consume it with or without food, but it's crucial to maintain consistency in timing each day. Taking more than the prescribed dose can cause severe side effects on the body.
Before consuming this medication, it is important to consult with your doctor, especially if you are currently undergoing treatment for any underlying condition. Pregnant or breastfeeding women should inform their doctor before starting this therapy. Throughout the treatment course, your doctor may recommend periodic laboratory tests to monitor the medicine's impact on your body. If you notice symptoms such as infection, alterations in mole appearance or size, abnormal growths or lumps, or unusual fatigue or weakness, it is important that you seek medical advice immediately.
Uses of Sirolimus tablet
Preventing kidney transplant rejection
Benefits of Sirolimus tablet
Preventing kidney transplant rejection
To prevent kidney transplant rejection, physicians use Siromus Sirolimus 1mg tablet along with other medications. Typically, rejection occurs when the recipient's immune system attacks the transplanted organ. This medication reduces the activity of the individual's immune system in kidney transplant recipients, preventing rejection episodes.
How to use Sirolimus 1mg tablet
Follow your doctor's guidance regarding the dosage and duration of this medication. Swallow the tablet whole; avoid chewing, crushing, or breaking it. You can take the Siromus Sirolimus 1mg tablet with or without food, but it's advisable to maintain a consistent time for administration.
How Sirolimus table works
Siromus 1mg Tablet acts as an immunosuppressant, functioning to suppress your body's immune response subsequent to an organ transplant (e.g., liver, kidney, heart). This mechanism allows your body to accept the new organ as if it were native.
Therapeutic Effects of Siromus 1mg tablet
Siromus 1mg Tablet is an immunosuppressant that reduces your body's immune system activity, shielding the transplanted organ from attack.
Siromus tablet compatibility with other medications
Inform your doctor about any prescribed medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products you are currently taking or have taken before starting treatment. Some medications may interact with the Siromus 1mg tablet, potentially reducing its effectiveness and leading to undesirable side effects.
More Information about Siromus 1mg tablet
1. Keep the Siromus 1mg tablet out of children's sight and reach.
2. Do not store above 25°C.
References
1. Pfizer Limited, Electronic medicines compendium (emc), [ Revised on July 2021] [ Accessed on 08th March 2023],https://www.medicines.org.uk/emc/files/pil.1368.pdf
2. Pfizer Limited, [ Revised on August 2023] [ Accessed on 08th March2023],https://labeling.pfizer.com/showlabeling.aspx?id=139.
3. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Targeted therapies: Tyrosine kinase inhibitors, monoclonal antibodies, and cytokines, 12th edition, 2011, 1735.
FAQ - Siromus
1Will Siromus 1mg Tablet affect fertility?
Siromus 1mg tablets can decrease the sperm count, which returns to a normal state after treatment. For more fertility concerns, talk with your doctor.
2Can Siromus 1mg Tablet cause any injury to the kidney?
Siromus 1 mg can damage the kidney, with or without rashes (hemolytic uraemic syndrome). Talk with your doctor before starting this medicine.
3What should I be aware of before taking Siromus 1mg Tablet?
If you are intolerant of some sugars, like lactose and sucrose, inform your doctor before the treatment. Additionally, avoid taking the Siromus 1mg Tablet with grapefruit or its juice.
4Can Siromus 1mg Tablet, cause diabetics?
The Siromus 1mg tablet may affect blood sugar levels. So, regularly check your blood sugar levels and notify your doctor if there are any sudden changes.
5What should I inform my doctor before starting the Siromus 1mg Tablet treatment?
Inform your doctor if you have any history of lung or liver transplantation or hypersensitivity, because Siromus 1mg tablets are not recommended in such cases.
6Sirolimus
One type of immunosuppressant called sirolimus is a mTOR inhibitor. It is used to treat lymphangioleiomyomatosis, stop organ transplant rejection, and help adults with perivascular epithelioid cell tumors.
7Sirolimus drug
One type of immunosuppressant called sirolimus is a mTOR inhibitor. It is used to treat lymphangioleiomyomatosis, stop organ transplant rejection, and help adults with perivascular epithelioid cell tumors.
8Sirolimus side effects
1. Abnormal vision.
2. acne.
3. belching.
4. The skin may experience blistering, crusting, irritation, itching, or reddening.
There is a burning feeling in the chest or stomach.
5. There may be sensations of burning, crawling, itching, numbness, prickling, "pins and needles," or tingling.
6. constipation.
7. There is a persistent ringing, buzzing, or other unexplained noise in the ears.
9Sirolimus mechanism of action
Sirolimus combines with the intracellular protein FKBP12 to create an immunosuppressive complex. This complex blocks the activation of TOR, a cell-cycle-specific kinase. Consequently, this complex obstructs cell-cycle progression at the G1 and S phase junctions.
10Sirolimus vs Tacrolimus
The 1-year graft survival rate was 92% in the tacrolimus group and 94% in the sirolimus group, according to the Kaplan-Meier estimate (p = 0.95; Figure 1B). Death-censored 1-year graft survival rates were 96% in the tacrolimus group and 96% in the sirolimus group (p = 0.96).
Its main mode of action involves inhibiting the mammalian target of rapamycin (mTOR), a protein kinase crucial for regulating cell growth, proliferation, and survival.
13Tacrolimus vs Sirolimus
The 1-year graft survival rate was 92% in the tacrolimus group and 94% in the sirolimus group, according to the Kaplan-Meier estimate (p = 0.95; Figure 1B). Death-censored 1-year graft survival rates were 96% in the tacrolimus group and 96% in the sirolimus group (p = 0.96).
14Sirolimus cost
Sirolimus cost: INR 550/strip
15Mechanism of action of sirolimus
Sirolimus combines with the intracellular protein FKBP12 to create an immunosuppressive complex. This complex blocks the activation of TOR, a cell-cycle-specific kinase. Consequently, this complex obstructs cell-cycle progression at the G1 and S phase junctions.
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Sirolimus is used to prevent kidney transplant rejection. As an immunosuppressant, it works by suppressing your body's immune response after an organ transplant, such as a liver, kidney, or heart.
