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Cazanat 20mg tablet
₹4,900.00 Original price was: ₹4,900.00.₹2,650.00Current price is: ₹2,650.00.
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Salt Composition: Cabozantinib
Manufacturer: Natco Pharma Ltd
Packaging Size: 30 Tablets
Delivery Services
Categories: Anti Cancer, Cabozantinib, Kidney Cancer, Liver Cancer, Thyroid Cancer
Cazanat Cabozantinib 20mg tablet price in India
Cazanat Cabozantinib 20mg tablet is a categorized medicine known as a tyrosine kinase inhibitor, employed in the management of liver cancer, kidney cancer, and thyroid cancer.
For optimal benefits, Cazanat Cabozantinib 20mg tablets should be consumed on an empty stomach, preferably at the same time daily. Your doctor will determine the appropriate dosage and frequency based on your specific treatment needs, which may be subject to adjustments over time. Adhere strictly to the prescribed instructions, as improper intake or excessive dosage can lead to severe side effects. While it may take weeks or months to observe the benefits, continue taking the medication; do not stop unless your doctor instructs you to.
Prior to initiating the Cazanat 20mg tablet, inform your doctor about any history of heart disease, liver or kidney issues, or high blood pressure. It is crucial to disclose all medications you are currently taking because they might interact with or have an impact on this medication. Avoid using this medication during pregnancy or while breastfeeding. Both males and females should use effective contraception throughout the treatment to prevent unintended pregnancy. Keep your healthcare team informed about your medical history and current medications for a comprehensive assessment.
For optimal benefits, Cazanat Cabozantinib 20mg tablets should be consumed on an empty stomach, preferably at the same time daily. Your doctor will determine the appropriate dosage and frequency based on your specific treatment needs, which may be subject to adjustments over time. Adhere strictly to the prescribed instructions, as improper intake or excessive dosage can lead to severe side effects. While it may take weeks or months to observe the benefits, continue taking the medication; do not stop unless your doctor instructs you to.
Prior to initiating the Cazanat 20mg tablet, inform your doctor about any history of heart disease, liver or kidney issues, or high blood pressure. It is crucial to disclose all medications you are currently taking because they might interact with or have an impact on this medication. Avoid using this medication during pregnancy or while breastfeeding. Both males and females should use effective contraception throughout the treatment to prevent unintended pregnancy. Keep your healthcare team informed about your medical history and current medications for a comprehensive assessment.
Cabozantinib 20mg uses
1. Treatment of liver cancer
2. Treatment of kidney cancer
3. Treatment of thyroid cancer
2. Treatment of kidney cancer
3. Treatment of thyroid cancer
Cabozantinib 20mg tablet benefits
1. In the treatment of liver cancer
Liver cancer originates in the hepatocytes, the cells of the liver. In the early stages, the cancer may be asymptomatic, but as it progresses, symptoms such as weight loss, stomach pain, vomiting, and yellowed skin may manifest. Cazanat 20 Tablet is effective in eliminating cancer cells, inhibiting their growth, and preventing their spread to unaffected areas. To optimize recovery, it is crucial to abstain from alcohol and smoking, as their use can exacerbate your condition.2. In the treatment of kidney cancer
Cazanat 20 Tablet is prescribed for the treatment of kidney cancer and its related symptoms, including blood in the urine, unexplained low back pain or weight loss, fatigue, and loss of appetite. By halting cancer growth and impeding the multiplication of cancer cells, it curtails the progression of cancer to other unaffected areas. Adhering closely to your doctor's instructions is crucial for an effective recovery.3. In the treatment of thyroid cancer
Situated at the base of the neck, the thyroid is a gland with a butterfly-shaped structure responsible for producing hormones that regulate heart rate, blood pressure, body temperature, and weight. Thyroid cancer, occurring in thyroid cells, may initially be asymptomatic. Cazanat 20 Tablet acts by limiting the oxygen supply to cancer cells, impeding their growth, and preventing further spread. This medication is potent and highly toxic, necessitating a thorough discussion of its risks and benefits with your doctor. During treatment, it is advisable to abstain from alcohol and smoking while maintaining hydration through adequate water intake.How to use Cabozantinib 20mg tablet
Follow your doctor's guidance regarding the dose and duration of this medication. Consume the tablet whole, without chewing, crushing, or breaking it. It is recommended to take a Cazanat Cabozantinib 20mg tablet on an empty stomach.
How Cabozantinib 20mg tablet works
Cazanat Cabozantinib 20mg tablet works by stopping an abnormal protein from doing its job, which triggers the growth of cancer cells. This stops or slows the spread of cancer cells.
Therapeutic Effects of Cazanat Cabozantinib 20mg tablet
It counteracts a protein known as receptor tyrosine kinases, disrupting cell signaling and, in the end, arresting the growth and dissemination of cancer cells.
Cazanat Cabozantinib 20mg is prescribed either alone or in conjunction with Nivolumab.
Interaction of Cazanat Cabozantinib 20mg with other drugs
Notify your doctor about any prescribed medications, over-the-counter drugs, nutritional or vitamin supplements, and herbal products you are currently using or have used before commencing treatment. Specific medications, including antibiotics, St. John's Wort, Aliskiren, and others, may potentially interact with Cazanat 20mg, leading to undesirable side effects.
Fact Box of Cabozantinib (Cazanat) 20mg tablet
1. Molecule Name: cabozantinib
2. Therapeutic class: antineoplastic
3. Indications: Advanced renal cell carcinoma, Liver cancer, and differentiated thyroid cancer
2. Therapeutic class: antineoplastic
3. Indications: Advanced renal cell carcinoma, Liver cancer, and differentiated thyroid cancer
References
1. 2. Ipsen Pharma, Electronic Medicines Compendium (EMC), [Revised on July 2022] [Accessed on 25th 25, 2023],https://www.medicines.org.uk/emc/product/4331/smpc
2. Exelixis, Inc., [Revised on Oct 2020] [Accessed on 25th April 2023],https://www.cometriq.com/downloads/Cometriq_Full_Prescribing_Information.pdf
3. Gregory A. Brent and Ronald J. Koenig, Thyroid and Antithyroid Drugs, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 2018, 787-801.
2. Exelixis, Inc., [Revised on Oct 2020] [Accessed on 25th April 2023],https://www.cometriq.com/downloads/Cometriq_Full_Prescribing_Information.pdf
3. Gregory A. Brent and Ronald J. Koenig, Thyroid and Antithyroid Drugs, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 2018, 787-801.
FAQ - Cabozantinib
1Can Cabozantinib (cazanat) 20mg cause a lower level of albumin?
A frequent side effect of Cabozantinib (Cazanat) 20mg is a reduction in albumin levels. If you encounter any side effects, promptly get in touch with your physician.
2Why is it recommended to use effective contraception during the treatment of Cabozantinib (Cazanat) 20mg?
To prevent unintended pregnancies, it is recommended to use reliable contraception. Oral contraception might not be sufficient; hence, it is advisable to consult with your doctor regarding effective contraceptive methods.
3Why is liver enzyme getting elevated during treatment with Cabozantinib (Cazanat) 20mg?
The cause of this increase is not entirely comprehended, but it is believed to be linked to the drug's impact on specific enzymes responsible for liver function. The rise in liver enzymes is usually mild and temporary, typically resolving either spontaneously or with a dose adjustment of the Cazanat 20mg tablet.
4How can I manage diarrhea while taking Cabozantinib (Cazanat) 20mg?
In cases of diarrhea during the use of Cazanat 20mg, maintaining adequate hydration through increased fluid intake is crucial. Your doctor may suggest over-the-counter or prescription medications to assist in managing the diarrhea. If the diarrhea is severe or persists, it is advisable to consult your doctor.
5Is Cabozantinib (Cazanat) 20mg a chemotherapy drug?
Yes, Cazanat 20mg is classified as a chemotherapy medication and belongs to the category of tyrosine kinase inhibitors.
6Cabozantinib tablets
Cabozantinib tablets
Cabozantinib tablets function by impeding the growth of cancer cells, slowing down or halting their progression. These tablets are employed in the treatment of kidney, thyroid, and liver cancer.7Cabozantinib tablets in india
Cabozantinib tablets in india
1. Cabozanib 20mg, 40mg, 60mg2. Cazanat 20mg, 40mg, 60mg
3. Cabolong 20mg, 40mg, 60mg, etc
8Cabozantinib tablets side effects
Cabozantinib tablets side effects
1. Fatigue2. Rash
3. Nausea
4. Loss of appetite
5. Diarrhea
6. Abdominal pain
7. Vomiting
8. Weight loss
9. Infection
10. Edema (swelling)
11. Fever
12. Constipation, etc.
9Cabozantinib 20mg price in India
Cabozantinib 20mg price in India
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Cabozantinib 20mg price
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Cazanat 20mg price
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Cabozantinib 20mg tablet
Cabozantinib, also known as Cometriq and Cabometyx, is a targeted cancer drug used to treat kidney cancer that has spread to other parts of the body (advanced kidney cancer) and a type of thyroid cancer called medullary thyroid cancer that has also metastasized.16Cazanat 20 mg price
Cazanat 20 mg price
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Cazanat 20 mg cost in india
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Cazanat 20 mg cost
Cazanat 20 mg cost: INR 265028Cabozantinib mechanism of action
Cabozantinib mechanism of action
Cabozantinib is a tyrosine kinase inhibitor (TKI) that works by targeting multiple receptors involved in tumor growth, angiogenesis (the formation of new blood vessels), and metastasis (spread of cancer). Its mechanism of action is primarily through the inhibition of the following pathways: VEGFR (Vascular Endothelial Growth Factor Receptor): Cabozantinib inhibits VEGFR-1, -2, and -3, which play a crucial role in angiogenesis, helping tumors grow by supplying them with blood vessels. MET (Mesenchymal-Epithelial Transition Factor): Cabozantinib targets MET, a receptor involved in cell growth, survival, and migration. MET activation is associated with tumor invasion and metastasis. AXL (AXL Receptor Tyrosine Kinase): This receptor is implicated in cancer cell survival, migration, and resistance to therapy. Cabozantinib blocks AXL signaling. Ret Receptor Tyrosine Kinase: Ret is involved in cell signaling that promotes cancer growth. Cabozantinib also inhibits this receptor. By inhibiting these receptors, cabozantinib reduces tumor growth, limits the formation of new blood vessels within the tumor, and impedes cancer cell survival and spread. It is used in various cancers, such as renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer.29Cabozantinib package insert
Cabozantinib package insert
Cabozantinib is marketed under the brand names CABOMETYX and COMETRIQ, each with distinct formulations and indications. CABOMETYX is available in tablet form and is indicated for: - Advanced renal cell carcinoma (RCC) - Hepatocellular carcinoma (HCC) in patients previously treated with sorafenib - Differentiated thyroid cancer (DTC) refractory to radioactive iodine treatment The recommended dosage for CABOMETYX varies based on the specific condition and patient factors. For instance, in RCC, the typical starting dose is 60 mg orally once daily. However, dosage adjustments may be necessary for patients with hepatic impairment or when used in combination with other therapies. COMETRIQ is supplied in capsule form and is specifically approved for: - Progressive, metastatic medullary thyroid cancer (MTC) The recommended dose for COMETRIQ is 140 mg orally once daily, taken on an empty stomach. It's important to note that COMETRIQ capsules and CABOMETYX tablets are not interchangeable due to differences in dosing and bioavailability. Important Safety Information: Hemorrhage: Severe and fatal hemorrhages have been reported. Discontinue use for Grade 3 or 4 hemorrhages. Perforations and Fistulas: Serious cases, including fatalities, have occurred. Monitor for symptoms and discontinue if necessary. Thrombotic Events: Increased risk of thrombotic events, including heart attacks and strokes. Hypertension: Monitor blood pressure regularly; manage hypertension appropriately. Osteonecrosis of the Jaw: Perform oral examinations prior to initiation and periodically during treatment. Diarrhea: Common adverse reaction; manage promptly to prevent dehydration. For comprehensive information, including detailed dosing guidelines, contraindications, and a complete list of warnings and precautions, please refer to the full prescribing information provided by the U.S. Food and Drug Administration (FDA) for CABOMETYX and COMETRIQ . It's crucial to consult with a healthcare professional before starting treatment with cabozantinib to ensure it's appropriate for your specific medical condition and to discuss potential risks and benefits.30Cabozantinib prescribing information
Cabozantinib prescribing information
Cabozantinib is available under the brand names CABOMETYX and COMETRIQ, each with specific formulations and indications. CABOMETYX (cabozantinib) tablets are indicated for: Advanced Renal Cell Carcinoma (RCC): As monotherapy or in combination with nivolumab for first-line treatment. Hepatocellular Carcinoma (HCC): In patients previously treated with sorafenib. Differentiated Thyroid Cancer (DTC): In adults and pediatric patients 12 years and older with locally advanced or metastatic DTC refractory to radioactive iodine treatment. Dosage and Administration: Monotherapy: The recommended dose is 60 mg orally once daily. Combination with Nivolumab (for RCC): 40 mg orally once daily, with nivolumab administered intravenously. Administration: Take on an empty stomach; avoid eating for at least 2 hours before and 1 hour after dosing. Dose Adjustments: May be necessary based on individual tolerability and in cases of hepatic impairment. COMETRIQ (cabozantinib) capsules are indicated for: Progressive, Metastatic Medullary Thyroid Cancer (MTC). Dosage and Administration: Recommended Dose: 140 mg orally once daily. Administration: Take on an empty stomach; avoid eating for at least 2 hours before and 1 hour after dosing. Note: COMETRIQ capsules and CABOMETYX tablets are not interchangeable due to differences in dosing and bioavailability. Important Safety Information: Hemorrhage: Severe and fatal cases have been reported. Discontinue for Grade 3 or 4 hemorrhages. Perforations and Fistulas: Serious cases, including fatalities, have occurred. Monitor for symptoms; discontinue if necessary. Thrombotic Events: Increased risk of thrombotic events, including heart attacks and strokes. Hypertension: Monitor blood pressure regularly; manage hypertension appropriately. Osteonecrosis of the Jaw: Perform oral examinations prior to initiation and periodically during treatment. Diarrhea: Common adverse reaction; manage promptly to prevent dehydration. For comprehensive information, including detailed dosing guidelines, contraindications, and a complete list of warnings and precautions, please refer to the full prescribing information provided by the U.S. Food and Drug Administration (FDA) for CABOMETYX and COMETRIQ . It's crucial to consult with a healthcare professional before starting treatment with cabozantinib to ensure it's appropriate for your specific medical condition and to discuss potential risks and benefits.31Cabozantinib price
Cabozantinib price
Cabozantinib price INR 265032Cost of cabozantinib
Cost of cabozantinib
Cost of cabozantinib INR 265033Cabozantinib success stories
Cabozantinib success stories
Cabozantinib has shown significant efficacy in treating several types of cancers, with many patients experiencing positive outcomes. Here are some success stories and notable examples: 1. Renal Cell Carcinoma (RCC): Patient A: A patient with advanced RCC who had previously undergone surgery and other treatments experienced disease progression. After starting cabozantinib as a second-line treatment, the patient showed significant tumor shrinkage, leading to prolonged survival. The patient tolerated the treatment well, and their quality of life improved significantly during therapy. Patient B: A patient with metastatic RCC who had progressed on prior treatments was enrolled in a clinical trial of cabozantinib. The patient had a remarkable response, with nearly complete resolution of their metastatic lesions, leading to stable disease for over a year. The treatment helped delay further progression and improved overall survival. 2. Hepatocellular Carcinoma (HCC) Patient C A patient with HCC, previously treated with sorafenib, began cabozantinib treatment after disease progression. Within a few months, imaging showed substantial tumor shrinkage, and the patient had improved liver function. The patient continued to live without disease progression for several more months, demonstrating the effectiveness of cabozantinib as a second-line option for HCC. 3. Medullary Thyroid Cancer (MTC) Patient D: A patient diagnosed with advanced, progressive medullary thyroid cancer who had failed prior therapies started cabozantinib treatment. After several months, scans revealed a significant reduction in tumor size, and the patient experienced a significant improvement in symptoms, including reduced pain and improved mobility. 4. Thyroid Cancer: In various cases of differentiated thyroid cancer (DTC) resistant to radioactive iodine, cabozantinib has shown positive results. A number of patients experienced regression of distant metastases and had prolonged progression-free survival. These success stories, while encouraging, emphasize that patient responses to cabozantinib can vary, and it is crucial to work closely with healthcare providers to monitor treatment outcomes, manage side effects, and tailor the therapy to individual needs. Clinical trials and real-world evidence continue to demonstrate the potential of cabozantinib as a powerful treatment for multiple cancers, improving the prognosis for many patients.34Cabozantinib brand name
Cabozantinib brand name
1. CAZANAT 2. CABOZANIB 3. CABOMETYX 4. CABOLONG 5. COMETRIQ 6. CABOTIB 7. LUPIZOTIB 8. CABOTRESAll Substitutes
Product | Packaging Size | Manufacturer | Price |
---|---|---|---|
Cabolong 20mg tablet | 30 tablets | MSN Laboratories | INR 5100 |
Cabozanib 20mg tablet | 30 tablets | BDR Pharmaceuticals | INR 3850 |
Cabdual 20mg tablet | 30 tablets | Intas Pharmaceuticals | INR 3550 |
Cabozat 20mg tablet | 30 tablets | Sun Pharmaceutical | INR 3900 |
Cabotres 20mg tablet | 30 tablets | Cipla Ltd | INR 4650 |
Side Effects
Cabozantinib tablet side effects
1. Fatigue
2. Nausea
3. Diarrhea
4. Vomiting
5. Stomatitis (inflammation of the mouth)
6. High blood pressure
7. Decreased appetite
8. Taste change
9. Low blood platelets
10. Anemia (a low number of red blood cells)
11. Palmar-plantar erythrodysesthesia syndrome
12. Decrease in body weight
13. Increased liver enzymes
14. Dyspepsia
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