Palbociclib

This page provides detailed information about palbociclib, including its indications, dosage and administration, mechanism of action, related brands and strengths, warnings, and common side effects.

Context and Approval Date

Pfizer initially approved Palbociclib, an anticancer medication, in 2015 for treating postmenopausal women with hormone receptor-positive breast cancer. Subsequently, it gained approval for metastatic breast cancer treatment. Recently, it received approval for treating male breast cancer.

Mechanism of Action of Palbociclib

Palbociclib capsule exerts its action by inhibiting the signaling pathways of cyclin-dependent kinase 4 and 6 enzymes, which are critical for cancer cell proliferation. This medication effectively inhibits cell division by targeting it from the G phase to the S phase of the cell cycle.

All Substitutes

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Product Packaging Size Company Price
Piclib 125mg capsule 21 capsule Hetero Healthcare INR 3100
Ciclib 125mg capsule 21 capsule Shilpa Medicare INR 2700
Bdpalbo 125mg capsule 21 capsule BDR Pharmaceuticals INR 3200
Palnat 125mg capsule 21 capsule Natco Pharma INR 3650
Pabreca 125mg capsule 21 capsule Lupin Ltd INR 5600
Kixta 125mg capsule 21 capsule Zydus Cadila INR 5900

Uses of Palbociclib

We use palbociclib to treat hormone-positive breast cancer, usually in conjunction with other hormonal therapy agents. It proves effective in managing breast cancer that has metastasized to other organs.

Palbociclib administration guidelines and available dosage options

Palbociclib is designed for oral administration exclusively and is commonly prescribed alongside other hormonal therapy agents. It should be taken with meals, and the capsule should not be opened or broken. Pabociclib capsules are available in three strengths: 75 mg, 100 mg, and 125 mg.

Information about palbociclib

Palbociclib uses

Breast cancer patients are treated with palbociclib. Patients with certain types of breast cancer (estrogen receptor-positive, human epidermal growth factor receptor 2-negative) that have spread to other organs also receive treatment with palbociclib. It is administered in conjunction with hormonal anti-cancer therapies.

How palbociclib works

Palbociclib functions as an anti-cancer drug by targeting cyclin-dependent kinases 4 and 6, essential components in cell proliferation pathways. By stopping these kinases from working, it stops the cancer cell cycle from moving forward, especially in estrogen receptor-positive breast cancer cells, which stops their growth.

Common side effects of palbociclib

Fatigue, hair loss, Rash, Vomiting, Diarrhea, Nausea, Decreased appetite, Infection, Decreased white blood cell count, Stomatitis (inflammation of the mouth), Anemia (low number of red blood cells), weakness, Fever
1. Take it with food, preferably at the same time every day. 
2. If you forget to take the medicine or vomit, skip the missed dose and follow a regular schedule. Do not take a double dose to make up a missed dose.
3. Use effective contraception methods to prevent pregnancy while taking this medicine.
4. It may cause dizziness. Avoid driving or any activity requiring mental focus until you know how it affects you.
5. Regular blood tests may be required while taking this medication. If you notice symptoms of infection, such as fever, chills, and weakness, inform your doctor.
6. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.
7. Do not stop taking the medication without talking to your doctor first.

Warning, Precautions, and Side Effects Associated with Palbociclib

Warning

Palbociclib carries the risk of harm to an unborn baby, so consulting your doctor before planning a pregnancy is advisable. Follow adequate birth control measures for at least 3 weeks after treatment completion. Notify your doctor of any allergies to sugar compounds like lactose, as Palbociclib contains lactose. Avoid grapefruit consumption during treatment. Inform your doctor about any medications for cholesterol or heart diseases to prevent potential adverse effects.

Precautions

Before starting Palbociclib treatment, tell your doctor about your medication history. If you're taking antibiotics, antivirals, or antifungals, notify your doctor to prevent complications. Regular blood cell count monitoring is crucial during Palbociclib treatment due to potential declines in platelets and red and white blood cells. Inform your doctor of any liver disorders prior to starting treatment.

Side effects

During Palbociclib treatment, you may experience common side effects such as reduced white blood cell count, fatigue, loss of appetite, hair loss, dry skin, fever, changes in vision, diarrhea, and vomiting.

Word of advice

If you encounter breathing difficulties, chest pain, or fever with chills while taking Palbociclib, seek immediate medical assistance or inform your doctor, as it could indicate lung inflammation. Take Palbociclib tablets at the same time daily, preferably with a meal. Exercise caution when driving or operating machinery, as you may experience fatigue or dizziness during treatment. Minimize exposure to crowded places, practice frequent handwashing, and stick to home-cooked meals to lower the risk of infections.

FAQ - Palbociclib

1Yes, palbociclib is a form of targeted therapy.
Indeed, palbociclib is classified as a targeted therapy, falling under the category of cyclin-dependent kinase inhibitors.
2Palbociclib can cause hair lose?
Hair loss or thinning can be a side effect of taking Palbociclib. If you experience any side effects that concern you, it's important to consult your doctor for guidance.
3Children can use palbociclib?
Individuals under the age of 18, including adolescents and children, should not use palbociclib.
4Does palbociclib affect fertility?
Yes, palbociclib may reduce fertility in men, potentially impacting their ability to father a child. Therefore, men should consider sperm preservation before starting this medication.
5Does palbociclib affect blood cell count?
Palbociclib can decrease white blood cell count, potentially weakening the immune system and raising the risk of infection. We recommend regular blood tests while using Palbociclib to monitor these effects.
6What vitamins can be taken with palbociclib?
It's important to consult your doctor before taking any vitamins or nutritional supplements while using palbociclib, as certain vitamins may interact with its absorption.

References

1. Pfizer Limited, Electronic medicines compendium (emc), [Revised on June 2021] [ Accessed on 26 Nov 2022],https://www.medicines.org.uk/emc/files/pil.4449.pdf
2. Neha S Mangini et al; Palbociclib: A Novel Cyclin-Dependent Kinase Inhibitor for Hormone Receptor-Positive Advanced Breast Cancer; The Annals of Pharmacotherapy; Published on Nov 2015; Accessed on 26/11/2022;https://pubmed.ncbi.nlm.nih.gov/26324355/
3. Pfizer Labs, US Food and Drug Administration, [Revised on March 2017] [ Accessed on 26 Nov 2022],https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/207103s004lbl.pdf
4. Palbace; Pfizer; Revised on Oct 2021; Accessed on 26/11/2022; https://labeling.pfizer.com/ShowLabeling.aspx?id=14029