Dasatinib
This page provides detailed information on the drug dasatinib, covering its uses, recommended dosage and administration, mode of action, associated brands with their strengths, cautious notes, and possible side effects.
Context and Approval Date
Dasatinib, an anticancer medication, received medical approval for its use on June 28, 2006.
Mechanism of Action of Abiraterone Acetate
Dasatinib Tablet functions as a targeted therapy in cancer treatment and is classified as a tyrosine kinase inhibitor. These inhibitors target the BCR-ABL tyrosine kinase enzymes, which drive excessive white blood cell production in leukemia. By binding to both active and inactive sites of these enzymes, dasatinib curbs the unregulated proliferation of white blood cells.
All Substitutes
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| Product | Packaging Size | Company | Price |
|---|---|---|---|
| Dasanat 50mg tablet | 60 tablets | Natco Pharma | INR 3200 |
| Dash 50m tablet | 60 tablets | BDR Pharmaceuticals | INR 2100 |
| Spnib 50mg tablet | 60 tablets | Zydus Cadila | INR 2600 |
| Nextnib 50mg tablet | 60 tablets | Celon Laboratories | INR 2900 |
| Dasamyl 50mg tablet | 60 tablets | Mylan Pharmaceuticals | INR 3100 |
| Dasatrue 50mg tablet | 60 tablets | CIPLA Ltd | INR 3500 |
Uses of Dasatinib
Dasatinib Tablet is specifically designed for the treatment of Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia in adults, adolescents, and children who have not responded to prior treatments. Additionally, it is approved for the treatment of chronic myeloid leukemia.
Dasatinib administration guidelines and available dosage options
For adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia, the recommended initial dosage is 140 mg daily. The appropriate dosage for children depends on their body weight.
Information about Dasatinib
Dasatinib is used in the treatment of blood cancer, specifically chronic myeloid leukemia. It is administered to patients whose condition is unresponsive to other leukemia medications or who are unable to tolerate them due to adverse effects.
Common side effects of Dasatinib
Abdominal pain, Anemia (low number of red blood cells), Fatigue, Headache, Infection, Low blood platelets, Musculoskeletal (bone, muscle, or joint) pain, Nausea, Rash, Vomiting, Constipation, Diarrhea, Joint pain, Muscle pain, Fluid retention, Pleural effusion, Localized edema, Pulmonary hypertension (high blood pressure), Generalized edema, Pericardial effusion, Heart failure, Pulmonary edema, Hemorrhage, Gastrointestinal bleeding, Muscle spasm, Itching, Decreased white blood cell count (neutrophils), Decreased phosphate level in the blood, Decreased calcium level in the blood, Increased bilirubin in the blood, Increased creatinine level in the blood.Dasatinib functions as an anti-cancer drug by inhibiting the activity of an aberrant protein that triggers the multiplication of cancer cells. By doing so, it effectively halts or reduces the growth of cancerous cells.
Warning, Precautions, and Side Effects Associated with Dasatinib
Warning
Immediately contact your healthcare provider if you experience symptoms such as chest pain, breathing difficulties, coughing, fainting, unusual bleeding, unexplained bruising, fever, infections, a sore throat, or skin peeling. Your physician will conduct regular blood tests to assess the effectiveness of this medication. Dasatinib is not advisable for individuals with allergies, hepatitis B infection, or liver and heart complications. Inform your healthcare provider about any current or recent usage of other medications or herbal supplements.Precautions
Inform your doctor immediately if you are pregnant, suspect pregnancy, breastfeeding, or intend to get pregnant. The use of Dasatinib tablets is not advised during pregnancy or lactation. It is recommended for both genders to utilize reliable contraception throughout this treatment period.Side effects
The common side effects that are likely to occur while you are on the treatment with Dasatinib Tablet are diarrhea, headache, cough, rash, nausea, vomiting, tiredness, muscle pain, weakness, low appetite, and blood pressure fluctuations. Contact your health-care provider right away if you notice unusual bleeding, bruising, changes in consciousness, breathlessness, rapid heart rate, fever, or infection.Word of advice
Be cautious when driving or operating machinery, and immediately consult your healthcare provider if you experience side effects like dizziness or blurred vision. Prior to commencing this treatment, inform your doctor if you have been diagnosed with lactose intolerance.FAQ - Dasatinib
1What drugs should you avoid taking with Dasatinib tablets?
It is best to stay away from drugs like ritonavir, carbamazepine, phenobarbital, phenytoin, rifampicin, omeprazole, St. John's Wort, and antacids that contain aluminum hydroxide and magnesium hydroxide while taking dasatinib tablets.
2Are dasatinib tablets safe for women of reproductive age?
Dasatinib tablets are not recommended for use during pregnancy or breastfeeding. It is advisable for both men and women to utilize effective contraception while undergoing this treatment.
3Is it safe to undergo surgery while taking Dasatinib tablets?
Due to the increased risk of bleeding and bruising associated with Dasatinib tablets, it is important to consult your physician if you plan to undergo surgery or dental procedures while on this treatment.
4What is the recommended duration for taking dasatinib tablets?
Continue taking Dasatinib tablets until instructed otherwise by your healthcare provider. Stick to the prescribed duration of treatment as advised.
5What should you do if a Dasatinib tablet breaks?
While it's uncommon for Dasatinib tablets to break, if such an incident occurs, the patient's caregiver should wear gloves when handling them.
6What are the common side effects of Dasatinib tablets?
The most common side effects associated with Dasatinib tablets are diarrhea, headache, cough, rash, nausea, vomiting, tiredness, muscle pain, weakness, low appetite, and blood pressure fluctuations.
7When should you get in touch with your doctor?
Immediately reach out to your healthcare provider if you encounter chest pain, breathing difficulties, coughing, fainting, abnormal bleeding, unexplained bruising, fever, infection, sore throat, or skin peeling.
References
1. Tillomed Laboratories Ltd., Electronic Medicines Compendium (EMC), [Revised on Aug 2021] [Accessed on 13th Aug 2022], https://www.medicines.org.uk/emc/files/pil.11505.pdf
2. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
2. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
