Dolutegravir,lamivudine,tenofovir Disoproxil Fumarate

This page provides a quick overview of the drug combination Dolutegravir, Lamivudine, and Tenofovir Disoproxil Fumarate. It includes information on its uses, dosage, how it works, available brands and strengths, warnings, and common side effects.

Context and Approval Date

Dolutegravir, Lamivudine, and Tenofovir Disoproxil Fumarate are antiviral medicines combined into one treatment. This combination was officially approved for medical use on April 13, 2020.

Mechanism of Action of Dolutegravir,lamivudine,tenofovir Disoproxil Fumarate

Dolutegravir, Lamivudine, and Tenofovir Disoproxil Fumarate Tablet is a medicine used to treat HIV. It combines three drugs that help block the virus from multiplying in the body. This medicine boosts the number of CD4 T cells, which are important for the immune system. By strengthening the immune system, it helps fight infections, lowers the amount of HIV in the blood, and reduces the severity of the infection.

All Substitutes

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Product Packaging Size Manufacturer Price
Acriptega tablet 30 tablets Mylan Pharmaceuticals Pvt Ltd INR 2500
Xapavir LT Tablet 30 tablets Natco Pharma Ltd INR 1650
Viropil Tablet 30 tablets Emcure Pharmaceuticals Ltd INR 2250
Viropil Tablet 60 tablets Emcure Pharmaceuticals Ltd INR 6000

Uses of Dolutegravir,lamivudine,tenofovir Disoproxil Fumarate

Dolutegravir, Lamivudine, and Tenofovir Disoproxil Fumarate is a medicine used to treat HIV-1. It is a complete treatment for both adults and children with HIV-1, helping to control the virus and improve immune system health.

Dolutegravir,lamivudine,tenofovir Disoproxil Fumarate administration guidelines and available dosage options

Dolutegravir, Lamivudine, and Tenofovir Disoproxil Fumarate come in film-coated tablets. Each tablet contains 50mg of Dolutegravir, 300mg of Lamivudine, and 300mg of Tenofovir Disoproxil Fumarate. The usual dose is one tablet per day, which can be taken with or without food.

Information about Dolutegravir,lamivudine,tenofovir Disoproxil Fumarate

Dolutegravir, Lamivudine, and Tenofovir Disoproxil Fumarate are used to treat HIV-1 infection in adults and children. This combination medication helps:
1. Reduce the amount of HIV in the blood (viral load).
2. Increase CD4 T cells, which strengthen the immune system.
3. Slow the progression of HIV, improving quality of life.
4. Lower the risk of HIV-related complications, such as infections and certain cancers.

How Dolutegravir,lamivudine,tenofovir Disoproxil Fumarate works

Dolutegravir, Lamivudine, and Tenofovir Disoproxil Fumarate are medicines used to treat HIV. They work by blocking an enzyme called reverse transcriptase, which the virus needs to multiply. By stopping this enzyme, the medicine helps slow down the spread of HIV in the body.

Common side effects of Dolutegravir,lamivudine,tenofovir Disoproxil Fumarate

Common side effects may include:
1. Headache
2. Fever
3. Stomach pain
4. Weakness
5. Diarrhea
6. Nausea and vomiting
7. Joint pain
8. Difficulty sleeping (insomnia)
9. Digestive issues
10. Dizziness
11. Unusual dreams
12. Depression and anxiety
13. Itching and skin rash
14. Fatigue
15. Low phosphate levels in the blood
16. General discomfort
17. Cough
18. Increased liver enzyme levels
19. Hair loss
20. Muscle problems
1. Used for HIV Treatment: This medicine helps control HIV infection.
2. Take Every Dose on Time: Skipping doses can make the treatment less effective.
3. Best Taken on an Empty Stomach: Preferably at bedtime for better results.
4. Inform Your Doctor About Hepatitis B: If you have had hepatitis B before, let your doctor know.
5. Not Safe During Pregnancy or Breastfeeding: Avoid this medicine if you are pregnant or nursing.
6. May Lower Calcium Levels: Your doctor may check calcium and vitamin D levels and suggest supplements if needed.
7. Liver Monitoring Required: Regular liver function tests may be needed. Contact your doctor if you notice yellow skin or eyes, dark urine, or stomach pain.

Warning, Precautions, and Side Effects Associated with Dolutegravir,lamivudine,tenofovir Disoproxil Fumarate

Warnings

1. Do not take this medicine if you are allergic to Dolutegravir, Lamivudine, or Tenofovir Disoproxil Fumarate.
2. Use with caution if you have or are at risk of pancreatitis.
3. Regular check-ups: Your doctor may monitor your blood counts, bone strength, liver, and kidney health during treatment.
4. Inform your doctor if you have a history of heart failure, pancreatitis, bone disease, fractures, liver, or kidney problems.

Precautions

1. Use Birth Control: If you can become pregnant, use an effective contraceptive to avoid unwanted pregnancy.
2. Not Safe in Early Pregnancy: If you are pregnant or think you might be, your doctor may suggest a different treatment.
3. Avoid Breastfeeding: It is not recommended because HIV can pass from mother to baby through breast milk.

Side Effects

1. Common side effects: You may experience trouble sleeping, tiredness, headache, diarrhea, skin rash, pain, depression, cough, or fever while taking this medicine.
2. Serious side effects: In rare cases, it may cause bone loss, worsening of hepatitis B, kidney problems, immune system issues, lactic acidosis (a buildup of acid in the blood), or severe liver enlargement.
3. Seek medical help: If you have an allergic reaction after taking this tablet, contact your doctor immediately.

Word Of Advice

This medicine may cause tiredness, so avoid driving or operating machines while taking it.

FAQ - Dolutegravir,lamivudine,tenofovir Disoproxil Fumarate

1What medications or supplements should be avoided while taking Dolutegravir, Lamivudine, and Tenofovir Disoproxil Fumarate?
Avoid taking the following with Dolutegravir, Lamivudine, and Tenofovir Disoproxil Fumarate:

1. Antacids or supplements with calcium, magnesium, or iron (they can reduce the medicine's effectiveness)
2. Other HIV medications (unless prescribed by your doctor)
3. Rifampin or rifabutin (used for infections, as they may lower the drug’s effectiveness)
4. Certain seizure medications (like phenytoin, phenobarbital, or carbamazepine)
5. St. John’s Wort (a herbal supplement that may interfere with the medicine)

Always check with your doctor before taking any new medication or supplement.
2Is it safe to take Dolutegravir, Lamivudine, and Tenofovir Disoproxil Fumarate during pregnancy and while breastfeeding?
It is not recommended to take this medicine during early pregnancy, as it may harm the baby. If you are pregnant or planning to become pregnant, talk to your doctor about safer options. Breastfeeding is also not advised because HIV can pass to the baby through breast milk. Always consult your doctor for the best advice.
3When should you contact your doctor?
Contact your doctor if you have signs of an allergic reaction or lactic acidosis (a dangerous buildup of acid in the blood).
4What are the required laboratory parameters prior to starting this treatment?
If you are a teenager or an adult who can become pregnant, your doctor will do a pregnancy test before starting this treatment. Other important tests include checking for Hepatitis B, kidney function (serum creatinine and creatinine clearance), and urine tests for sugar and protein levels.
5How can you tell if you're allergic to Dolutegravir, Lamivudine, or Tenofovir Disoproxil Fumarate?
If you notice a severe rash, rash with fever, muscle pain, extreme tiredness, swelling of the face, trouble breathing, or skin blisters and peeling, contact your doctor immediately.
6What are the long-term side effects of this medication?
Serious long-term side effects may include worsening of hepatitis B, weak bones, kidney damage, pancreas problems, immune system issues, liver damage, and allergic reactions.
7What are the signs of lactic acidosis?
The main signs of lactic acidosis include extreme weakness, tiredness, muscle pain, trouble breathing, stomach pain, nausea, vomiting, dizziness, lightheadedness, irregular heartbeat, and feeling cold, especially in your arms and legs.

References

1. Lorus Generics Inc., U.S. Food and Drug Administration, [Revised on Jan 2021] [Accessed on 27th Aug 2022],https://www.accessdata.fda.gov/drugsatfda_docs/pepfar/210787PI.pdf
2. Adis International Ltd., Springer Nature, [Accessed on 27th Aug 2022],https://adisinsight.springer.com/drugs/800058512
3. KD Tripathi, Antiviral Drugs (Antiretrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019, 860-872.