Jaknat Tofacitinib Tablets 5mg is a medicine used to treat moderate to severe conditions like:
Rheumatoid arthritis
Psoriatic arthritis
Ankylosing spondylitis
Ulcerative colitis
It helps by reducing joint pain, swelling, and tenderness. It can also slow down damage to your joints and bones.
You can take tofacitinib tablets by itself or with other medicines. Take it with or without food, but try to take it at the same time every day. The dose depends on your condition and any other medicines you're taking, so always follow your doctor’s instructions. Don’t stop taking it without talking to your doctor, as it may make your condition worse.
Before starting tofacitinib tablets, you might need blood tests. Don’t use it if you have an infection. Talk to your doctor first if you have or had:
Tuberculosis (TB)
Shingles
Liver or kidney problems
Hepatitis B or C
Blood clots in the legs or lungs
This medicine can make it easier to catch infections or make current ones worse. Avoid being around people who have contagious illnesses like chickenpox, measles, or the flu.
Tofacitinib is not for use in people under 18. It may not be safe if you are pregnant or breastfeeding—check with your doctor first. Regular check-ups may be needed while taking this medicine.
Tofacitinib tablet uses
Treatment of Rheumatoid arthritis
Treatment of Psoriatic arthritis
Treatment of Ankylosing spondylitis
Treatment of Ulcerative colitis
Treatment of Alopecia
Tofacitinib tablet benefits
🦴 For Rheumatoid Arthritis
Tofacitinib tablets helps reduce joint pain, swelling, and stiffness by blocking the chemicals that cause inflammation. It also protects your joints from long-term damage. Taking it regularly—even if you feel better—can help keep symptoms under control and improve your daily life.
🦵 For Psoriatic Arthritis
This type of arthritis affects people with psoriasis (a skin condition that causes dry, scaly patches). It leads to joint pain and swelling that can come and go. Tofacitinib helps reduce pain and stiffness, improves movement, and slows down the disease, helping you feel better and move more easily.
🧍‍♂️ For Ankylosing Spondylitis
This is a kind of arthritis that mainly affects the spine and large joints, starting from the lower back. Tofacitinib helps reduce back and joint pain, improves flexibility, and slows down the disease, making it easier to stay active and live comfortably.
This condition causes swelling in the colon and rectum, leading to symptoms like diarrhea, stomach pain, and bleeding. Tofacitinib tablets helps reduce these symptoms and keeps them from coming back. It's also important to drink plenty of water while taking this medicine.
How to use Tofacitinib tablet
1. Take as Prescribe
Always follow your doctor’s instructions. Do not change the dose on your own.
2. How Often to Take
Usually taken once or twice a day, depending on your condition.
3. With or Without Food
You can take it with or without food, but try to take it at the same time every day.
4. Swallow Whole
Swallow the tablet with water. Do not crush, chew, or break it.
5. Don't Skip Doses
If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed one—don’t double up.
Don’t Stop Suddenly
Keep taking it even if you feel better, unless your doctor tells you to stop.
Important Tips
Get blood tests done as your doctor recommends.
Tell your doctor if you get any infections, fever, or unusual symptoms.
Avoid close contact with people who have contagious illnesses like flu or chickenpox.
How Tofacitinib tablet works
Tofacitinib tablets are a type of medicine called a JAK inhibitor (Janus Kinase inhibitor).
In conditions like arthritis or ulcerative colitis, your immune system becomes overactive and starts attacking your own body, causing inflammation, pain, and swelling.
Tofacitinib works by:
Blocking certain enzymes (JAKs) in your immune cells.
This reduces the activity of the immune system.
As a result, it lowers inflammation, relieves pain and stiffness, and prevents further joint or tissue damage.
Therapeutic Effects of Jaknat Tofacitinib Tablets 5mg
Jaknat 5mg tablet comes under the category of Janus Kinase Inhibitors and functions as a disease-modifying anti-rheumatic drug (DMARD). Janus kinase, a type of tyrosine kinase enzyme, plays a role in cytokine receptor signaling. The tablet works by inhibiting Janus kinases, disrupting the transcription of genes associated with cell growth and differentiation.
Interaction of Jaknat Tofacitinib Tablets 5mg with other drugs
Ensure you communicate with your healthcare provider regarding all the medications you are using, encompassing prescription drugs, over-the-counter medications, vaccinations, nutritional and vitamin supplements, as well as herbal products. Some medications might interact with the Jaknat 5mg tablet, potentially diminishing their effectiveness and giving rise to undesirable side effects.
More Information about Tofacitinib Tablet
Store tofacitinib at room temperature (20°C to 25°C).
Keep the tablet out of the reach of children and pets.
If you forgot to take a dose, take it as soon as you remember.
However, if it is nearly time for the next dose, skip the missed dose.
Do not take a double dose to make up for a forgotten dose.
XELJANZ 5 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. www.medicines.org.uk. [cited 2023 Mar 25]. Available from: https://www.medicines.org.uk/emc/product/2500/smpc
FAQ - Tofacitinib
1What are the cautions of Tofacitinib tablet?
If you notice any swelling in your face, lips, tongue, throat, arms, or legs, or experience difficulty swallowing or breathing, inform your doctor promptly. The use of Jaknat 5mg tablets may lead to a temporary reduction in white blood cell count, elevating the risk of infection.
2Does Tofacitinib tablet cause high cholesterol?
Increased cholesterol levels can result from the use of tofacitinib tablets. Your doctor may check routine blood tests to monitor potential serious side effects.
3 Can Tofacitinib tablet cause depression?
No, Tofacitinib tablets do not cause depression. Nevertheless, individuals with autoimmune conditions often experience symptoms of depression. If you are encountering signs of depression, it is advisable to promptly consult your doctor.
4Does Tofacitinib tablet cause blood clots?
Yes, blood clots are reported in patients using tofacitinib tablets for a longer period of time. Inform your physician if you experience any symptoms of a blood clot.
5How long does it take Tofacitinib (Jaknat) 5mg tablet to work?
Jaknat 5mg tablets are administered as a long-term treatment. Individuals who derive benefit from this course of treatment typically observe improvement within the initial 12 weeks of starting it.
6Tofacitinib citrate
The production of tofacitinib citrate involves the combination of equimolar quantities of tofacitinib and citric acid. People with moderate to severe rheumatoid arthritis are given this medicine, which works as both an antirheumatic and a non-specific protein-tyrosine kinase (EC 2.7.10.2) inhibitor. Tofacitinib is a key component of this formulation.
7Tofacitinib 5mg price in India
Tofacitinib 5mg price in India INR 1500
8Tofacitinib alopecia
Tofacitinib citrate, initially designed as a Janus kinase 1/3 inhibitor for rheumatoid arthritis, is currently repurposed for the treatment of alopecia areata. In this investigation, scientists systematically examined the medical records at the Cleveland Clinic to identify individuals with confirmed alopecia areata who underwent treatment with oral tofacitinib following a standardized regimen.
9Tofacitinib mechanism of action
Tofacitinib hinders intracellular signaling from the receptor to the cellular nucleus and suppresses inflammation through a unique pathway—specifically, the inhibition of Janus kinases—an avenue not accessible to biological medicines.
10Tofacitinib side effects
1. Black, tarry stools.
2. bladder pain.
3. bloody or cloudy urine
4. body aches or pain.
5. chest pain or tightness.
6. difficult, burning, or painful urination.
7. difficulty breathing.
8. ear congestion.
11Tofacitinib brand name
Tofacitinib, sold under the brand name Xeljanz among others like Tofajak, Jakura, Jaknat, T Jaki, etc,
12Tofacitinib vitiligo
Vitiligo is a skin disorder of autoimmune origin characterized by depigmented areas on the skin.
13Topical tofacitinib
Vitiligo is an autoimmune skin condition leading to depigmented skin areas. Recent research suggests that Janus kinase (JAK) inhibitors could be a viable treatment. Our case study involves an adolescent patient with an extensive and resistant history of vitiligo. After using a JAK inhibitor called tofacitinib on the skin for 9 months and phototherapy, there was a lot of repigmentation, which shows that the treatment worked.
14Tofacitinib 5mg price
Tofacitinib 5mg price: INR 313
15Tofacitinib 5 mg price
Tofacitinib 5 mg price: INR 313
16Tofacitinib 5mg price in india
Tofacitinib 5mg price in india: INR 313
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Tofacitinib 5 mg price in india: INR 313
18Tofacitinib 5mg tablet price
Tofacitinib 5mg tablet price: INR 313
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Tofacitinib 5 mg tablet price: INR 313
20Jaknat 5mg price
Jaknat 5mg price: INR 313
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Jaknat 5 mg price: INR 313
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Jaknat 5 mg price in india: INR 313
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24Tofacitinib 5mg tablet
Tofacitinib 5mg tablet
Tofacitinib is used, either alone or in combination with other medications, to treat rheumatoid arthritis in adults. This condition, where the body attacks its own joints, leads to pain, swelling, and loss of function. Tofacitinib is prescribed for patients who cannot take or did not respond to one or more tumor necrosis factor (TNF) inhibitors.
