Human Albumin
This page provides detailed information regarding human albumin, including its indications, dosage and administration guidelines, mechanism of action, associated brands with strengths, warnings, and common side effects.
Context and Approval Date
Human Albumin Injection is a solution containing albumin for injection purposes, granted approval by the US Food and Drug Administration for medical use on August 4, 2014.
Mechanism of Action of Human Albumin
The primary mechanism of action of human albumin injection is to elevate colloidal osmotic pressure, thereby reducing fluid accumulation. This process involves drawing fluid from the intravascular space, consequently augmenting circulatory blood volume.
All Substitutes
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| Product | Packaging Size | Company | Price |
|---|---|---|---|
| Alburel 20%/100ml Injection | 1 Injection | Reliance Lifesciences | INR 5000 |
| Takeda 20%/100ml Injection | 1 Injection | Takeda Pharmaceuticals | INR 4650 |
| Albucel 20%/100ml Injection | 1 Injection | Intas Pharmaceuticals | INR 5150 |
Uses of Human Albumin
We formulate Human Albumin Injection to address hypovolemia, hypoalbuminemia, cardiopulmonary bypass surgery, and hemolytic disease of the newborn.
Human Albumin administration guidelines and available dosage options
Human albumin is provided in both 5% and 20% solutions for injection. Human albumin injections are typically administered via intravenous infusion. Your doctor will determine the appropriate dosage tailored to your health condition and body weight.
In instances of hypovolemic shock in infants and young children, the suggested dose falls within the range of 2.5 to 5 ml per kg of body weight. For older children and adults, the usual dose typically lies between 100 and 200 ml. Patients with hypoalbuminemia are typically recommended a dose of 80 to 100 mL per kg of body weight. Newborns diagnosed with hemolytic disease are advised to take 1 gram per kg of body weight either before or during the exchange transfusion.
In instances of hypovolemic shock in infants and young children, the suggested dose falls within the range of 2.5 to 5 ml per kg of body weight. For older children and adults, the usual dose typically lies between 100 and 200 ml. Patients with hypoalbuminemia are typically recommended a dose of 80 to 100 mL per kg of body weight. Newborns diagnosed with hemolytic disease are advised to take 1 gram per kg of body weight either before or during the exchange transfusion.
Information about Human Albumin
We use albumin for short-term fluid replenishment after trauma and in cases of nephrotic syndrome.
How Human Albumin works
Human albumin, a native protein in the bloodstream, makes up albumin. Its function is to replenish lost blood or body fluids caused by excessive bleeding, surgery, or kidney dialysis.Common side effects of Human Albumin
Flushing (sense of warmth in the face, ears, neck, and trunk), Fever, chills, nausea, vomiting, Anaphylactic shock, Heart failure, Pulmonary edema, Hypotension (low blood pressure), Tachycardia, Urticaria, Rash, Headache. 1. A medical professional supervises the injection into the veins.
2. Inform your doctor immediately if you experience a skin rash, itching, breathing difficulties, swelling of the face, or changes in your heartbeat while using this medicine.
3. Inform your doctor if you have a history of severe anemia (lack of red blood cells) or severe heart failure.
2. Inform your doctor immediately if you experience a skin rash, itching, breathing difficulties, swelling of the face, or changes in your heartbeat while using this medicine.
3. Inform your doctor if you have a history of severe anemia (lack of red blood cells) or severe heart failure.
Warning, Precautions, and Side Effects Associated with Human Albumin
Warning
If you experience symptoms like shortness of breath, fever, or severe bleeding, contact your physician promptly. Throughout your human albumin injection therapy, your doctor may regularly monitor your white blood cell counts, platelets, blood clotting factors, blood sugar levels, electrolytes, and kidney function to prevent potential complications. Make sure to inform your doctor about any history of heart failure, hypertension, esophageal varices, pulmonary edema, bleeding disorders, severe anemia, or kidney disease. Seek immediate medical attention if you have allergic reactions, headaches, or breathing difficulties, as these symptoms may suggest underlying heart problems.Precautions
The potential for human albumin injection to cause harm to the fetus or pass into breast milk is currently unknown. Nonetheless, it is recommended to inform your healthcare provider if you are pregnant, breastfeeding, or planning to conceive before commencing this treatment.Side Effects
The common side effects that are likely to occur while you are on the treatment with human albumin injection are headache, vomiting, nausea, rash, pruritus, fever, chills, low BP, and flushing. Hypersensitivity, pulmonary edema, rapid heart rate, and breathlessness are some of the severe adverse reactions of human albumin injection, and you should report them to your healthcare provider right away if you experience any of these symptoms.Word Of Advice
We recommend regularly monitoring your blood pressure throughout this treatment. Avoid driving or operating machinery if you experience dizziness or visual disturbances. Applying a cool compress to the injection site can help alleviate pain.FAQ - Human Albumin
1How is Human Albumin Injection administered?
Human albumin injection is administered intravenously via infusion, with the dosage determined according to the patient's body weight, age, and overall health condition.
2Is human albumin injection safe for women of reproductive age to use?
As the potential effects of human albumin injection on the fetus or breast milk are uncertain, it's advisable to inform your healthcare provider if you are pregnant, breastfeeding, or planning to conceive before starting this treatment.
3What should you know before using a human albumin injection?
It's critical to realize that diluting albumin solution with sterile water can cause hemolysis and acute kidney injury.
4Who should avoid using human albumin injection?
Individuals with a hypersensitivity to human albumin or its components should avoid using human albumin injection. Furthermore, it is not advisable for individuals with severe anemia, heart failure, or kidney problems to use this medication.
5Will you be monitored during this treatment?
Indeed, your human albumin treatment will involve continuous monitoring. Your healthcare provider will regularly evaluate your blood pressure, heart rate, electrolyte levels, and complete blood count.
6What are the initial indicators of hypersensitivity reactions?
Hives, generalized urticaria, chest tightness, breathlessness, wheezing, low blood pressure, and faintness are among the most common early signs of hypersensitivity reactions.
7How should Human Albumin Injection be stored?
Keep the human albumin injection at room temperature (below 30°C) and utilize it promptly upon opening. After administering, dispose of any remaining unused portion.
References
1. Campos Munoz A, Jain NK, Gupta M. Albumin Colloid. [Updated 2022 Jun 27]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan, [Accessed on 25th Aug 2022],https://www.ncbi.nlm.nih.gov/books/NBK534241/
2. Baxalta US Inc., US Food & Drug Administration, [Revised on Aug 2019] [Accessed on 25th Aug 2022],https://www.fffenterprises.com/assets/downloads/pi-Albumin-PPF_FLEXBUMIN%2025_Baxter.pdf
2. Baxalta US Inc., US Food & Drug Administration, [Revised on Aug 2019] [Accessed on 25th Aug 2022],https://www.fffenterprises.com/assets/downloads/pi-Albumin-PPF_FLEXBUMIN%2025_Baxter.pdf
