Azel Enzalutamide 80 mg is a medicine used to treat prostate cancer. It works by blocking certain hormones (called androgens) that help cancer cells grow. By stopping these hormones from reaching the cancer cells, it helps slow down or stop the cancer from spreading. The dose and how long you need to take it will depend on your specific condition and how your body responds to the treatment. Important: This medicine is not safe for pregnant or breastfeeding women. Always take it exactly as your doctor tells you.
You can take Enzalutamide 80 mg with or without food, but try to take it at the same time every day. Always follow your doctor’s instructions for how much to take and how often—your dose may change over time based on how your body responds. Important tips:
Never take more than the prescribed dose. Taking it the wrong way or in higher amounts can lead to serious side effects.
It may take a few weeks or even months to notice the benefits, so keep taking it unless your doctor tells you to stop.
Let your doctor know if you have diabetes, seizures, or liver or kidney problems, or if you’re taking any other medicines.
Both men and women should avoid getting pregnant during treatment.
Your doctor may check your blood sugar levels regularly while you're on this medicine.
Always stay in touch with your doctor and report any unusual symptoms right away.
Uses of Enzalutamide capsule
Prostate cancer
Benefits of Enzalutamide capsule
The prostate is a small, walnut-shaped gland in men that produces fluid to help carry and protect sperm. Prostate cancer can sometimes cause trouble with urination, but in some cases, it might not show any symptoms at all. Enzalutamide 80 mg works by lowering the effects of testosterone, a male hormone that helps prostate cancer cells grow. By blocking this hormone, the medicine helps slow down the cancer and can also ease urinary problems, making you feel more comfortable and improving daily function.
Therapeutic Effects of Azel Enzalutamide 80 mg
Azel works by blocking the effects of testosterone, especially its active form called dihydrotestosterone (DHT). It does this by targeting androgen receptors—these are like “docking stations” on cells that testosterone needs to connect with in order to send growth signals. When Azel blocks these receptors, testosterone can't attach or send signals to the cancer cells. This stops the hormone from reaching the cell’s DNA, which slows down or stops the growth of prostate cancer cells.
Interaction of Enzalutamide Capsule with other drugs
Make sure to tell your doctor about everything you're taking—this includes prescription medicines, over-the-counter drugs, vitamins, nutritional supplements, and herbal products. Some of these may interact with Azel Enzalutamide 80 mg, which can either reduce its effectiveness or cause unwanted side effects. Always keep your healthcare provider updated to stay safe and get the best results from your treatment.
More Information about Enzalutamide capsule
Store the Enzalutamide capsule in the original package at room temperature (20°C to 25°C).
Keep it out of reach of children and pets.
How to consume Enzalutamide Capsule
Your doctor will decide the right dose and how long you need to take Azel 80mg based on your condition and other health factors. Always follow your doctor’s instructions carefully.
The usual dose is 160 mg once a day—this means taking two 80mg tablets at the same time each day, with or without food. Important reminders:
Swallow the tablets whole with water. Do not chew, crush, or break them.
Swallow the tablets whole with water. Do not chew, crush, or break them.
If you miss a dose, just take the next one at your regular time. Don’t take two doses at once to make up for it.
Marina D. Kaymakcalan and Christy S. Harris, Prostate Cancer, Applied Therapeutics, The Clinical Use Of Drugs, 11th Edition, 2018, 2083-2100.
FAQ - Enzalutamide
1What tests are necessary before starting treatment with Enzalutamide capsule?
Before starting treatment with Enzalutamide (Azel) capsules, your doctor may recommend several tests to ensure the medication is safe and suitable for you. These may include:
1. Blood Tests
Complete Blood Count (CBC): To check for anemia or low white blood cell/platelet counts.
Liver Function Tests (LFTs): To make sure your liver is working properly, since Enzalutamide is processed by the liver.
Kidney Function Tests (RFTs): To assess kidney health, especially if you have a history of kidney problems.
Electrolyte levels: To monitor sodium, potassium, and calcium levels, which can be affected during treatment.
Blood Glucose Level: Especially if you have diabetes or are at risk—Enzalutamide may affect glucose metabolism.
2. PSA (Prostate-Specific Antigen) Test
To help measure the level of prostate cancer activity and serve as a baseline for monitoring treatment progress.
3. Seizure Risk Assessment
Enzalutamide can increase the risk of seizures. If you have a history of seizures, brain injury, or are on medications that affect the nervous system, your doctor may do a neurological evaluation or adjust treatment accordingly.
4. ECG or Cardiac Evaluation
If you have a history of heart problems, your doctor might recommend an electrocardiogram (ECG) or other heart tests to assess baseline heart function.
5. Hormone Levels (Optional)
In some cases, doctors may test testosterone or androgen levels to help track treatment impact.
2What should you do if you missed a dose of Enzalutamide capsule?
If you miss a dose of Enzalutamide (Azel), here’s what you should do:
Take the missed dose as soon as you remember—but only if it’s still close to the time of your next dose.
If it’s almost time for your next dose, skip the missed dose. Do not take two doses at once to make up for the one you missed.
Follow your regular dosing schedule going forward.
It’s important not to double up on doses, as this could increase the risk of side effects. Always check with your doctor or pharmacist if you're unsure about what to do after missing a dose.
3Who should not take Enzalutamide capsule?
Enzalutamide capsules should not be taken by certain individuals, including:
1. Women who are pregnant or breastfeeding
Enzalutamide can harm an unborn baby and may pass into breast milk, so it should not be used by pregnant or breastfeeding women.
2. Individuals with a history of seizures
Enzalutamide can increase the risk of seizures. If you have a history of seizures or other brain-related conditions, you may need to avoid this medication or take it with extra caution.
3. People with severe liver problems
Enzalutamide is processed by the liver, so if you have severe liver issues (e.g., cirrhosis), you should not take this medication, or your doctor may adjust the dosage.
4. Children
Enzalutamide is not approved for use in children and should not be prescribed to minors.
5. People who are allergic to Enzalutamide or any of its ingredients
If you have had an allergic reaction to Enzalutamide or any part of the medication, you should not take it.
If you’re unsure whether Enzalutamide is safe for you, it’s important to discuss your medical history and any existing conditions with your doctor before starting treatment.
4Can you smoke while on treatment with Enzalutamide capsule?
There are no direct warnings about smoking specifically interacting with Enzalutamide (Azel), but it's important to keep in mind the following:
1. General Health Impact
Smoking can worsen health conditions like heart disease, lung disease, and cancer. While on treatment for prostate cancer with Enzalutamide, it's especially important to maintain overall health, as smoking can interfere with your body’s ability to fight illness.
2. Potential for Increased Side Effects
Smoking may increase the risk of certain side effects such as cardiovascular issues or lung complications, which could make managing cancer treatment more difficult.
3. Impact on Cancer Progression
Smoking can also contribute to faster cancer progression or complications, so avoiding it during cancer treatment is often recommended.
It's always a good idea to discuss any lifestyle habits, including smoking, with your doctor to better manage treatment and reduce any potential risks.
5Enzalutamide mechanism of action
Enzalutamide works in three different ways. At the AR level, it is a powerful, competitive androgen binder. It inhibits the movement of the AR from the cytoplasm to the nucleus. It prevents AR from binding to chromosomal DNA within the nucleus, preventing tumor genes from being transcribed further.
6Enzalutamide prostate cancer
Enzalutamide is a medication that men who have benefited from specific medical and surgical procedures that lower testosterone levels can use to treat prostate cancer that has spread to other parts of the body.
7Enzalutamide moa
Enzalutamide works in three different ways. At the AR level, it is a powerful, competitive androgen binder. It inhibits the movement of the AR from the cytoplasm to the nucleus. It prevents AR from binding to chromosomal DNA within the nucleus, preventing tumor genes from being transcribed further.
