Xtandi 40mg capsule

The recommended test before starting treatment with Enzalutam capsules is prostate-specific antigen (PSA) testing. This blood test assesses the concentration of PSA, a protein generated by the prostate gland, which may be heightened in individuals with prostate cancer.

Do not overdose if you missed the dose of Enzalutamide capsule. Accidentally, if you take an extra dose, report it to your healthcare provider.

Enzalutamide capsule is not recommended for pregnant or breastfeeding women because this drug can harm an unborn baby or pass into breast milk.

No, it is not recommended for the patient to smoke cigarettes while on treatment because smoking can reduce the concentration of this drug in the body.

Enzalutamide mechanism of action

Enzalutamide works in three different ways. At the AR level, it is a powerful, competitive androgen binder. It inhibits the movement of the AR from the cytoplasm to the nucleus. It prevents AR from binding to chromosomal DNA within the nucleus, preventing tumor genes from being transcribed further.

Enzalutamide prostate cancer

Enzalutamide is a medication that men who have benefited from specific medical and surgical procedures that lower testosterone levels can use to treat prostate cancer that has spread to other parts of the body.

Enzalutamide moa

Enzalutamide works in three different ways. At the AR level, it is a powerful, competitive androgen binder. It inhibits the movement of the AR from the cytoplasm to the nucleus. It prevents AR from binding to chromosomal DNA within the nucleus, preventing tumor genes from being transcribed further.

Xtandi side effects

Xtandi (enzalutamide) is a medication prescribed for certain types of prostate cancer. Like all medications, it can cause side effects, ranging from mild to serious.
Common Side Effects
These are frequently reported and may be manageable with medical guidance:

Fatigue or tiredness

Hot flashes

Diarrhea

Muscle or joint pain

Headache

Dizziness

Swelling (edema)

High blood pressure

Back pain

Weight loss or decreased appetite

Anxiety or nervousness

Sleep disturbances

Memory or concentration issues

Serious Side Effects
These require immediate medical attention:

Seizures

Posterior reversible encephalopathy syndrome (PRES)

Falls and fractures

Heart problems

Allergic reactions

Swelling of the face, lips, or tongue

Chest pain or shortness of breath

Difficulty swallowing or choking

Long-Term and Rare Effects

Bone thinning (osteoporosis)

Breast enlargement in men (gynecomastia)

Low sodium levels in the blood

Visual disturbances

Restless leg syndrome

Monitoring and Management
Regular monitoring is essential to manage side effects effectively. This includes:

Blood pressure checks

Bone density scans

Neurological assessments

If you experience any side effects, consult your healthcare provider promptly. They can provide guidance on managing symptoms and determine whether adjustments to your treatment are necessary.

Xtandi cost

INR 160,000 ($1884)

life expectancy after xtandi fails

When Xtandi (enzalutamide) stops working—often referred to as progression after Xtandi—the prognosis and life expectancy for patients with metastatic castration-resistant prostate cancer (mCRPC) can vary significantly. It depends on factors like:

Disease burden and spread (e.g., bone, liver, or lymph node metastases)

PSA doubling time

Overall health and performance status

Response to subsequent treatments

📊 General Life Expectancy After Xtandi Fails
Clinical data suggests the following average survival range:

10 to 18 months is a common estimate after Xtandi failure, depending on what treatments are used next and the patient's condition.

This estimate comes from real-world studies and clinical trials in which patients moved on to other treatments after failing on enzalutamide or abiraterone.

🔄 What Are the Next Treatment Options?
After Xtandi failure, doctors may consider:

Chemotherapy – e.g., docetaxel or cabazitaxel

Radiopharmaceuticals – such as Pluvicto (Lu-177-PSMA-617) or Radium-223

PARP inhibitors – e.g., olaparib or rucaparib, especially in patients with BRCA mutations

Clinical trials – novel agents or immunotherapy

Immunotherapy – like pembrolizumab, for patients with MSI-high or mismatch repair-deficient tumors

🧬 Personalized Prognosis
Patients with certain favorable biomarkers (e.g., low tumor volume, no liver metastases, slow PSA rise) may live much longer even after Xtandi failure—sometimes 2+ years or more with aggressive treatment.
On the other hand, patients with poor performance status and rapidly progressing disease may have a shorter life expectancy.

✅ What You Can Do

Reassess cancer genomics – Ask your oncologist about genomic profiling to identify next-line therapies.

Consider second-line therapy early – Delaying treatment after progression may worsen outcomes.

Get a second opinion – Especially from a cancer center with experience in advanced prostate cancer.

Xtandi medication

Xtandi is the brand name for enzalutamide, a prescription medication used primarily to treat prostate cancer. It works by blocking the effects of androgens (male hormones like testosterone), which can fuel the growth of prostate cancer cells.

🔬 What Xtandi Is Used For
Xtandi is FDA-approved to treat:
1. Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Prostate cancer that has spread and no longer responds to hormonal therapy.

2. Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

Prostate cancer that has spread but still responds to hormone-lowering treatments.

3. Non-metastatic Castration-Resistant Prostate Cancer (nmCRPC)

Prostate cancer that hasn’t spread, but continues growing despite low testosterone levels.

💊 Dosage and Administration

Typical dose: 160 mg once daily, taken as four 40 mg capsules or tablets.

Can be taken with or without food.

Should be taken at the same time each day.

Continue androgen deprivation therapy (like a GnRH analog or surgical castration) during Xtandi use.

⚙️ How Xtandi Works (Mechanism of Action)
Xtandi is an androgen receptor inhibitor. It:

Blocks androgens (like testosterone and dihydrotestosterone) from binding to the androgen receptor.

Prevents the receptor from entering the cancer cell nucleus.

Reduces the cancer cell's ability to grow and multiply.

⚠️ Side Effects
Common:

Fatigue

Hot flashes

Back pain

Diarrhea

High blood pressure

Serious (but less common):

Seizures

Falls and fractures

Heart problems

Posterior reversible encephalopathy syndrome (PRES)

❗ Important Precautions

May increase risk of seizures, especially in patients with a seizure history.

May affect cognitive function (e.g., memory, attention).

Use with caution in patients with cardiovascular disease or those prone to falls.

💲 Cost & Access

List price: ~$14,900/month without insurance.

Copay programs and financial assistance are available through XTANDI Support Solutions.

xtandi uses​

Xtandi (enzalutamide) is a prescription medication primarily used for prostate cancer. It’s an androgen receptor inhibitor that blocks the action of male hormones (androgens) which help prostate cancer cells grow.

✅ FDA-Approved Uses of Xtandi
1. Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Definition: Prostate cancer that has spread beyond the prostate and continues to grow despite low testosterone levels (due to medical or surgical castration).

Xtandi is often used alone or with other hormone therapies.

2. Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

Definition: Cancer that has spread (metastasized) but still responds to treatments that lower testosterone.

Xtandi is used in combination with a GnRH analog or after surgical castration.

3. Non-Metastatic Castration-Resistant Prostate Cancer (nmCRPC)

Definition: Cancer that has not yet spread, but is growing despite very low testosterone levels.

Xtandi helps delay the spread (metastasis) of the cancer.

🧬 How Xtandi Helps

Blocks androgen receptors in prostate cancer cells.

Stops androgens from driving tumor growth.

Delays disease progression and helps patients live longer.

🏥 Sometimes Used Off-Label For:
(Not officially approved by the FDA, but sometimes prescribed based on clinical judgment)

Patients with early-stage high-risk prostate cancer not responding well to initial therapy.

Those who cannot tolerate other treatments like chemotherapy.

💡 Key Point
Xtandi is not used for other types of cancer or for non-cancerous prostate conditions (like BPH). It is specifically tailored to advanced prostate cancer management, especially when the disease becomes resistant to standard hormone therapy.

Xtandi generic

Generic versions of Xtandi (enzalutamide) are available in India. Prices start at approximately INR 15,696 (around $184.60) for a box containing 112 capsules.

Xtandi price

INR 160,000 ($1884)